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Myasthenia Gravis Treatment Guidelines Part 1

The Myasthenia Gravis is now fairly well researched from a medical perspective. Only a few decades myasthenic are regularly died of their disease because lack of information about Myasthenia disease, myasthenia gravis today no shortening effect of longer life expectancy. There are a whole range of treatment options that attach to different points. Usually several ways to combine, in part, the methods are useful only in combination. Which medications should be taken in what dosage and what options are displayed when, can be set only individually. Experience of the physician is therefore essential for successful treatment of major importance.

The following information is collected from a layman’s medical and shaped by personal experience, they do not claim to scientific precision. Above all, they can not replace a visit to the myasthenia doctor!

Improvement of the attraction transmission

As the first and most important possibility of treatment the attraction transmission at the synapses is improved by medicines. Functions, as the dismantling of the chemical messenger acetyl choline is braked.  Several means stand to the selection, which work within short time, whose effect in addition, only short time continue.

Treatment of the immune system

With the treatment of the immune system can go a step further: the treatment of the immune system to slow down the formation of antibodies and stopping misguided at best, almost completely. For this are various medications and some treatments are available.

* Cortisone
Cortisone is a hormone that occurs naturally in the body is. For the treatment of many inflammatory diseases and to curb exuberant immune cortisone is produced artificially. In the treatment of myasthenia cortisone is used very successfully, strangely enough, it can happen in the first 2-3 weeks after starting treatment with temporary worsening of myasthenia.

* Immunosuppressants
Because in the long term steroid treatment may have relatively many side effects, other drugs are often used to slow the formation of antibodies. The effect of these medical treatment begins only very slowly, usually with an improvement after 3 to 4 months to be expected, but it may take up to two years until the success of treatment is evident. The treatment is therefore more long-term.

* Plasmapheresis and immuno adsorption
In myasthenia crisis and in severe cases, the antibodies can be mechanically removed from the blood. Plasmapheresis, part of the blood plasma is removed, as a substitute, there is human albumin or donor plasma. In immuno adsorption, the plasma is similar to a blood cleaning “. Both methods are relatively expensive and complex, so that improvement can be achieved fairly quickly, however. To prevent that, the body produces then – almost to compensate – particularly large number of antibodies that are usually used simultaneously cortisone and / or immunosuppressants. The effect of this treatment options may continue for several months to years.

* Immuno globulins
Conjugate is administered as an infusion. Like immuno adsorption plasmapheresis and IVIG are used in severe cases and in myasthenic crisis. The effect is roughly comparable, as in the two previously mentioned methods.

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