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Signs and Symptoms of Hepatic Cirrhosis Complications

Patients with cirrhosis may have little or no liver disease symptoms and liver disease. Some cirrhosis symptoms may be nonspecific, i.e. not suggest that the liver is the cause. Among the most common symptoms and signs of cirrhosis, it’s include : itching, fatigue, loss of appetite, weakness, jaundice (yellowing of the skin) due to accumulation of bilirubin in the blood, and easy bruising of the decreased production of blood coagulation by the diseased liver.

Some cirrhosis patients also develop signs and symptoms of cirrhosis complications. The complications of cirrhosis such as edema and ascites, Spontaneous bacterial peritonitis (SBP), Bleeding esophageal varices described here, and Hepatic encephalopathy, Hepatorenal syndrome, Hepatopulmonaire Syndrome, Hypersplenism and Liver cancer (hepatocellular carcinoma) will be explained in part 2.

Edema and ascites

As liver cirrhosis is severe, the signals are sent to the kidneys retain salt and water in the body. The excess salt and water is first stored in the tissue under the skin of the ankles and legs due to gravity standing or sitting. This fluid buildup is called swelling or edema marks. (Fovea refers to the fact that the pressure of a finger firmly against the ankle or leg with edema causes bleeding in the skin that persists for some time after pressure release. In fact, any pressure, as the elastic of a sock, can be enough to cause pitting.) Swelling is often worse at the end of the day, after standing or sitting and may lower overnight due to the loss the effects of gravity on the position supine. As cirrhosis worsens and more salt and water is conserved, the fluid can also accumulate in the abdominal cavity between the abdominal wall and abdominal organs. This accumulation of fluid (called ascites) causes abdominal bloating, abdominal discomfort, and weight gain.

Spontaneous bacterial peritonitis (SBP)

Of fluid in the abdominal cavity (ascites) is the ideal place for bacteria to grow. Normally, the abdominal cavity contains a very small amount of liquid that is able to resist infection well, and bacteria that enter the abdomen (usually the intestine) are killed or find their place in the door and the liver vein, which killed. In cirrhosis, fluid accumulates in the abdomen can not normally resist infection. In addition, more bacteria find their way from the intestine into the ascites. Therefore, the infection within the abdomen and ascites, known as spontaneous bacterial peritonitis or SBP, is likely to happen. SBP is a potentially fatal complication. Some patients with PAS have no symptoms, while others may have fever, chills, abdominal pain, diarrhea, and worsening ascites.

Bleeding esophageal varices

In cirrhosis of the liver, scar tissue blocks the flow of blood to the heart of the intestines and increases the pressure in the portal vein (portal hypertension). When the pressure in the portal vein is large enough, which causes blood flow to the liver through the veins with less pressure to reach the heart. The most common veins through which blood passes through the liver are the veins along the lower esophagus and upper stomach.

Because of increased blood flow and thereby increasing the pressure, the veins of the lower esophagus, upper stomach and the expansion and then called esophageal and gastric varices, portal pressure, varicose veins more and more likely that a patient is bleeding from varices in the esophagus or stomach.

Bleeding varices are often severe and, without immediate treatment can be fatal. Symptoms of bleeding varices are vomiting blood (vomiting can be red blood mixed with clots or “coffee” in appearance, the latter due to the effect of acid in the blood), passage of stool that is black and tarry stools, due to changes in the blood that passes through the intestine mane () and dizziness or fainting hypotension (caused by a fall in blood pressure, especially when standing in the supine position).

It may also be bleeding from varices that form in other parts of the intestine, for example, the colon, but this is rare. For unknown reasons, patients hospitalized with active bleeding from esophageal varices are at high risk for spontaneous bacterial peritonitis.

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Hepatic Cirrhosis Problems for Patients

Do you know that liver is an important organ in the body? It serves many critical functions, which both produce substances the body needs, for example, coagulation of proteins needed for blood to clot, and removing toxic substances that may be harmful to the the body for example, drugs. The liver also plays an important role in regulating the supply to the body of glucose (sugar) and lipids (fats), your body uses as fuel. To perform these critical functions, the liver cells are functioning normally and have an intimate relationship with blood and the substances that are added or removed by the liver, are transported to and from the liver through the blood.

The ratio of liver to blood is unique. Unlike most organs in the body, only a small amount of blood supplied to the liver through the arteries. Most liver supply of blood comes from the intestinal veins return blood to the heart. The main vein that returns blood from the intestine is called the portal vein. That the portal vein through the liver, the veins have been divided into smaller and smaller. The smaller veins (called sinusoids because of its unique structure) are in close contact with liver cells. In fact, the liver cell line along the length of the sinusoids. This close relationship between liver cells and blood of the portal vein allows liver cells to remove and add substances in the blood. Once the blood has passed through the sinusoids, it is collected in the veins become larger and eventually to form a single vein, hepatic vein that returns blood to the heart.

In hepatic cirrhosis (also known as la cirrosis hepática, cirrosi epatica, cirrhose hépatique), it destroys the relationship between blood and liver cells. Although liver cells that survive or are newly formed, may be able to produce and eliminate substances in the blood are not normal, intimate relationship with the blood, which interferes with the ability of liver cells “for add or remove substances in the blood. In addition, the cirrhotic liver scarring obstructs the flow of blood through the liver and liver cells. Because of the obstruction to blood flow in the liver, blood “Returns” in the portal vein, and increases the pressure in the portal vein, a condition called portal hypertension. Due to the obstruction to flow and high pressure in the portal vein, blood from the portal vein to veins other than return to the heart, veins with lower pressures that pass through the liver. Substances Unfortunately, the liver is unable to add or remove the blood flowing through it. It is a combination of reduction in the number of liver cells, loss of normal contact between the blood through the liver and liver cells and blood bypassing the liver which leads to many manifestations of cirrhosis.

A second reason for the problems caused by the cirrhosis altered the relationship between liver cells and the channels through which the flow of bile. Bile is a liquid produced by the cells of the liver has two important roles in digestion and helps remove and eliminate toxic substances from the body. The bile produced by liver cells is secreted in very small channels that run between the cells of liver sinusoids, called canaliculi. The canaliculi drain into small ducts which then merge to form ducts of larger and larger. Ultimately, all channels combined in a tube that enters the small intestine. Thus, the bile into the intestine, where it can help to digest food. Meanwhile, the toxic substances contained in bile in the intestine and then excreted in feces. In cirrhosis, the tubules are abnormal and the relationship between liver cells and canaliculi is destroyed, as the relationship between liver cells and blood in the sinusoids. Consequently, the liver is unable to eliminate toxic substances that normally, and can accumulate in the body.  To a lesser extent of digestion in the intestine is also reduced.

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Definition and Question About Cirrhosis

This is cirrhosis definition, some people ask what’s liver cirrhosis ? Cirrhosis is a complication of many liver diseases characterized by a structure and abnormal liver function. Cirrhosis of the liver in United Kingdom or United States, also known as liver cirrhosis, liver fibrosis, hepatic cirrhosis, Cirrhose du foie en France, Cirrosi epatica in Italia, Leberzirrhose in Deutschland, Cirrose van de lever in Nederland, цирроз печени в России, la cirrosis del hígado en España, Türkiye’de karaciğer sirozu.

The diseases that cause cirrhosis do so because they injure and kill liver cells, and inflammation and repair that is associated with liver cells die causes scarring. Liver cells do not die, they multiply in an attempt to replace cells that have died. The resulting newly formed groups of liver cells (regenerative nodules) in scar tissue.

There are many causes of cirrhosis, they include chemicals (such as alcohol, fat, and certain drugs), viruses, toxic metals (such as iron and copper accumulate in the liver following genetic diseases), and autoimmune disease of the liver, which attacks the immune system attacks the body in the liver.

I will give explanation more detail at next articles about hepatic cirrhosis (liver cirrhosis), also cirrhosis signs and symptoms, liver fibrosis treatment, hepatic fibrosis diagnosis and causes, prevention from liver cirrhosis also hepatic cirrhosis doctor, hospital, also medical center.

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