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Cirrhosis Management Prevention in Futures

Progress in the hepatic cirrhosis prevention and management of cirrhosis continues. Research is underway to determine the mechanism of scar formation in the liver and how the healing process can be halted or even reversed. The newest and best treatments for viral diseases of the liver are being developed to prevent progression to cirrhosis. Prevention of viral hepatitis by vaccination, which is available for hepatitis B, is in development for hepatitis C. The treatment of complications of cirrhosis are continuously developed and tested. Finally, the research aims to identify new proteins in the blood can detect liver cancer early or predict which patients will develop liver cancer.

Hepatic Cirrhosis Disease Brief Information

• Cirrhosis disease is a liver complication disease leading to loss of liver cells and irreversible scarring of the liver.
• Alcohol and viral hepatitis C and hepatitis C are common causes of cirrhosis, although there are many other causes.
• Cirrhosis can cause bruising, weakness, loss of appetite, yellowing of the skin (jaundice), fatigue and itching.
• The cirrhosis diagnosis can be suggested by history, blood tests and physical examination, and can be confirmed by liver biopsy.
• The complications of liver cirrhosis are edema and ascites, variceal bleeding, spontaneous bacterial peritonitis, hepatic encephalopathy, hypersplenism, hepatorenal syndrome, Hepatopulmonary syndrome and liver cancer.
• Treatment of cirrhosis is designed to prevent more damage to the liver, treatment of complications of cirrhosis, and prevention or early detection of liver cancer.
• Liver transplantation is becoming an important option for treating patients with advanced cirrhosis.

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Prevention Liver Cancer Detection and Transplantation

In this session, I will explain in detail about liver cancer prevention and early detection of liver cancer, and cirrhosis liver transplantation .

Prevention liver cancer and early detection of liver cancer

There are several types of disease that causes liver cirrhosis associated with a particularly high incidence of liver cancer, for example, hepatitis B and C, and would be useful to detect liver cancer and early surgical treatment or Liver transplantation can cure the cancer patient. The difficulty is that the methods available for research are only partially effective in identifying, at best, only 50% of patients in a curable stage of cancer. Despite the partial effectiveness of screening, most patients with cirrhosis, hepatitis B and C, are reviewed annually or every six months with liver ultrasound and measurement of proteins produced by cancer in the blood, for example , alpha-fetoprotein.

Cirrhosis Liver Transplantation

Cirrhosis is irreversible. Liver function in many patients become progressively worse despite treatment and complications of cirrhosis will increase and become difficult to treat. Therefore, when advanced cirrhosis, liver transplantation is often the only option for treatment. Recent advances in transplant surgery and drugs to prevent infection and rejection of the transplanted liver had significantly improved survival after transplantation. On average, over 80% of patients who receive transplants are alive after five years. Not all people with cirrhosis is a candidate for transplantation. Furthermore, there is a shortage of livers for transplantation, and usually have a (long months or years) to wait before a liver transplant to make it available. Therefore, measures to slow the progression of liver disease and to treat and prevent complications of cirrhosis are of vital importance.

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Diabetes Cirrhosis Treatment to Prevent Liver Damage

The treatment of diabetes cirrhosis treatment include : prevent further damage to the liver, treatment of complications of cirrhosis, early detection and prevention of liver cancer, and liver transplantation.

And I will explain more detail the diabetes cirrhosis treatment steps, starting from how to prevent further damage to the liver.

• Eat a balanced diet and a daily multivitamin. PBC patients with impaired absorption of fat soluble vitamins may need supplements of vitamins D and K.
• Avoid drugs (including alcohol) that causes liver damage. All patients with cirrhosis should avoid alcohol. Most patients with cirrhosis induced by alcohol experience an improvement in liver function with abstinence from alcohol. Even patients with hepatitis B and C can significantly reduce liver damage and slow the progression to cirrhosis with alcohol withdrawal.
• Avoid anti-inflammatory drugs (NSAIDs, eg ibuprofen). Patients with cirrhosis may experience a worsening of liver and kidney with NSAIDs.
• Reducing hepatitis B and hepatitis C using anti-viral drugs. All patients with cirrhosis from chronic viral hepatitis are candidates for drug therapy. Some patients may experience a severe deterioration of liver function and / or intolerable side effects during treatment. Therefore, decisions to treat viral hepatitis should be individualized after consultation with physicians experienced in treating liver diseases (hepatologists).
• Removal of blood from patients with hemochromatosis to reduce iron levels and prevent further damage to the liver. In Wilson’s disease, medications can be used to increase copper excretion in the urine to reduce levels of copper in the body and prevent further damage to the liver.
• Remove the immune system with drugs such as prednisone and azathioprine (Imuran) to reduce inflammation of the liver in autoimmune hepatitis.
• Treat patients with primary biliary cirrhosis with a preparation of bile acid, ursodeoxycholic acid (UDCA), also called ursodiol (Actigall). The results of an analysis that combines results from several clinical trials have shown that UDCA improved survival in patients with PBC during 4 years of treatment. The development of portal hypertension has also been reduced by UDCA. Importantly, despite evident benefits, UDCA treatment delays progression and above all, not a cure for PBC. Other drugs such as colchicine and methotrexate may also have benefits for subgroups of patients with PBC.
• Patients with cirrhosis of immunizing against infection with hepatitis A and B to prevent a serious deterioration of liver function. There is currently no vaccine available for immunization against hepatitis C.

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