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Cirrhosis Management Prevention in Futures

Progress in the hepatic cirrhosis prevention and management of cirrhosis continues. Research is underway to determine the mechanism of scar formation in the liver and how the healing process can be halted or even reversed. The newest and best treatments for viral diseases of the liver are being developed to prevent progression to cirrhosis. Prevention of viral hepatitis by vaccination, which is available for hepatitis B, is in development for hepatitis C. The treatment of complications of cirrhosis are continuously developed and tested. Finally, the research aims to identify new proteins in the blood can detect liver cancer early or predict which patients will develop liver cancer.

Hepatic Cirrhosis Disease Brief Information

• Cirrhosis disease is a liver complication disease leading to loss of liver cells and irreversible scarring of the liver.
• Alcohol and viral hepatitis C and hepatitis C are common causes of cirrhosis, although there are many other causes.
• Cirrhosis can cause bruising, weakness, loss of appetite, yellowing of the skin (jaundice), fatigue and itching.
• The cirrhosis diagnosis can be suggested by history, blood tests and physical examination, and can be confirmed by liver biopsy.
• The complications of liver cirrhosis are edema and ascites, variceal bleeding, spontaneous bacterial peritonitis, hepatic encephalopathy, hypersplenism, hepatorenal syndrome, Hepatopulmonary syndrome and liver cancer.
• Treatment of cirrhosis is designed to prevent more damage to the liver, treatment of complications of cirrhosis, and prevention or early detection of liver cancer.
• Liver transplantation is becoming an important option for treating patients with advanced cirrhosis.

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Prevention Liver Cancer Detection and Transplantation

In this session, I will explain in detail about liver cancer prevention and early detection of liver cancer, and cirrhosis liver transplantation .

Prevention liver cancer and early detection of liver cancer

There are several types of disease that causes liver cirrhosis associated with a particularly high incidence of liver cancer, for example, hepatitis B and C, and would be useful to detect liver cancer and early surgical treatment or Liver transplantation can cure the cancer patient. The difficulty is that the methods available for research are only partially effective in identifying, at best, only 50% of patients in a curable stage of cancer. Despite the partial effectiveness of screening, most patients with cirrhosis, hepatitis B and C, are reviewed annually or every six months with liver ultrasound and measurement of proteins produced by cancer in the blood, for example , alpha-fetoprotein.

Cirrhosis Liver Transplantation

Cirrhosis is irreversible. Liver function in many patients become progressively worse despite treatment and complications of cirrhosis will increase and become difficult to treat. Therefore, when advanced cirrhosis, liver transplantation is often the only option for treatment. Recent advances in transplant surgery and drugs to prevent infection and rejection of the transplanted liver had significantly improved survival after transplantation. On average, over 80% of patients who receive transplants are alive after five years. Not all people with cirrhosis is a candidate for transplantation. Furthermore, there is a shortage of livers for transplantation, and usually have a (long months or years) to wait before a liver transplant to make it available. Therefore, measures to slow the progression of liver disease and to treat and prevent complications of cirrhosis are of vital importance.

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Diabetes Cirrhosis Treatment to Prevent Liver Damage

The treatment of diabetes cirrhosis treatment include : prevent further damage to the liver, treatment of complications of cirrhosis, early detection and prevention of liver cancer, and liver transplantation.

And I will explain more detail the diabetes cirrhosis treatment steps, starting from how to prevent further damage to the liver.

• Eat a balanced diet and a daily multivitamin. PBC patients with impaired absorption of fat soluble vitamins may need supplements of vitamins D and K.
• Avoid drugs (including alcohol) that causes liver damage. All patients with cirrhosis should avoid alcohol. Most patients with cirrhosis induced by alcohol experience an improvement in liver function with abstinence from alcohol. Even patients with hepatitis B and C can significantly reduce liver damage and slow the progression to cirrhosis with alcohol withdrawal.
• Avoid anti-inflammatory drugs (NSAIDs, eg ibuprofen). Patients with cirrhosis may experience a worsening of liver and kidney with NSAIDs.
• Reducing hepatitis B and hepatitis C using anti-viral drugs. All patients with cirrhosis from chronic viral hepatitis are candidates for drug therapy. Some patients may experience a severe deterioration of liver function and / or intolerable side effects during treatment. Therefore, decisions to treat viral hepatitis should be individualized after consultation with physicians experienced in treating liver diseases (hepatologists).
• Removal of blood from patients with hemochromatosis to reduce iron levels and prevent further damage to the liver. In Wilson’s disease, medications can be used to increase copper excretion in the urine to reduce levels of copper in the body and prevent further damage to the liver.
• Remove the immune system with drugs such as prednisone and azathioprine (Imuran) to reduce inflammation of the liver in autoimmune hepatitis.
• Treat patients with primary biliary cirrhosis with a preparation of bile acid, ursodeoxycholic acid (UDCA), also called ursodiol (Actigall). The results of an analysis that combines results from several clinical trials have shown that UDCA improved survival in patients with PBC during 4 years of treatment. The development of portal hypertension has also been reduced by UDCA. Importantly, despite evident benefits, UDCA treatment delays progression and above all, not a cure for PBC. Other drugs such as colchicine and methotrexate may also have benefits for subgroups of patients with PBC.
• Patients with cirrhosis of immunizing against infection with hepatitis A and B to prevent a serious deterioration of liver function. There is currently no vaccine available for immunization against hepatitis C.

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Cirrhosis Diagnosis and Evaluation Methods

The best test for the diagnosis of cirrhosis is a liver biopsy. Liver biopsies on cirrhosis diagnosis, however, has a low risk of serious complications and, therefore, biopsy is usually reserved for patients in whom the diagnosis of the type of disease or the presence of liver cirrhosis is unclear. The possibility that cirrhosis can be suggested by history, physical examination or routine tests. If cirrhosis is present, other tests may be used to determine the severity of cirrhosis and presence of complications. The tests also can be used to diagnose the underlying disease causes cirrhosis. Here are some examples of how doctors learn to diagnose and assess cirrhosis :

• Taking the history of the patient, the doctor may discover a history of prolonged and excessive consumption of alcohol, a history of intravenous drug abuse, or history of hepatitis. This information suggests the possibility of liver disease and cirrhosis.
• Patients who are known to have chronic viral hepatitis B or C are more likely to have cirrhosis.
• Some patients had cirrhosis of liver hypertrophy and / or spleen. A doctor can often feel (palpate) the lower edge of an enlarged liver below the right rib cage and feel the tip of the spleen in the left ribcage. A cirrhotic liver also feels firmer and more irregular than normal liver.
• Auto-antibodies (antinuclear antibodies, anti-smooth muscle antibodies and anti-mitochondria) are sometimes detected in the blood and can be a sign of the presence of autoimmune hepatitis or primary biliary cirrhosis, both can lead to cirrhosis.
• Liver cancer (hepatocellular carcinoma) can be detected by CT and MRI or ultrasound of the abdomen. Liver cancer occurs more frequently in individuals with underlying cirrhosis.
• Some patients with cirrhosis, alcoholic cirrhosis, especially, have small red spider-like markings (telangiectasias) on the skin, especially in the chest, consisting of enlarged blood vessels radiate. These spider telangiectasias can be observed in individuals without liver disease, however.
• Patients with abnormal deposits of copper in the eye or certain types of neurological May has Wilson’s disease, a genetic disease in which there is manipulation and abnormal accumulation of copper in the body like the liver, which can lead to cirrhosis.
• May is unexpectedly esophageal varices during upper endoscopy (EGD), suggesting cirrhosis.
• Computed Tomography (CT or CAT) or magnetic resonance imaging (MRI) and ultrasound examinations of the abdomen done for reasons other than to evaluate the possibility of liver disease in May unexpectedly detect abnormal liver hypertrophy nodular liver, enlarged spleen, and fluid in the abdomen suggest cirrhosis.
• Jaundice (yellowing of the skin and whites of the eyes due to elevated levels of bilirubin in the blood) is common in patients with cirrhosis, but jaundice can occur in patients suffering from liver cirrhosis and other conditions such as hemolysis (excess red blood cells break down).
• Swelling of the abdomen (ascites) and / or legs (edema) due to fluid retention is common in patients with cirrhosis of many other illnesses can make routinely, for example, congestive heart failure.
• The advanced cirrhosis leads to a lower level of albumin in the blood and reduces clotting factors due to the loss of the ability of the liver to produce these proteins. Therefore, the decreased levels of albumin in the blood suggest cirrhosis or abnormal bleeding.
• Abnormal elevation of liver enzymes in the blood (such as ALT and AST), which are regularly supplied as part of annual health examinations suggest that inflammation or liver damage from many causes, and cirrhosis.
• Patients with high levels of iron in the blood may have hemochromatosis, a genetic disease of the liver in which iron is handled in an abnormal way, leading to cirrhosis.
• If there is an accumulation of fluid in the abdomen, a fluid sample can be removed using a long needle. The liquid may be inspected and tested. Test results may suggest the presence of cirrhosis as the cause of the fluid.

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The Most Frequent Cirrhosis Causes

There are some causes of cirrhosis, such as alcohol, non-alcoholic fatty liver disease (NAFLD), cryptogenic cirrhosis, chronic viral hepatitis, Inherited disorders, primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, biliary atresia, and cardiac chronic heart failure as cirrhosis causes problems.

• Alcohol cause hepatic cirrhosis

Alcohol is a very common cause of cirrhosis, especially in the western world. The development of cirrhosis depends on the amount and regularity of alcohol consumption. Chronic high levels of alcohol consumption for liver cell damage. Thirty percent of people drinking daily for at least eight to sixteen ounces of hard liquor or the equivalent of fifteen or more years will develop cirrhosis. Alcohol causes a range of diseases of the liver to be simple and uncomplicated fatty liver (steatosis), to more severe fatty liver with inflammation (nonalcoholic steatohepatitis or hepatitis), cirrhosis.

• Non-alcoholic Fatty Liver Disease (NAFLD)

NAFLD, better known as Non-Alcoholic Fatty Liver Disease refers to a broad spectrum of liver diseases such as alcoholic liver disease, ranging from simple steatosis to non-alcoholic steato-hepatitis (NASH) to cirrhosis. All stages of NAFLD have in common the accumulation of fat in liver cells. The term is used because NAFLD nonalcoholic occurs in people who do not consume excessive amounts of alcohol, however, in many respects, the microscopic image of non-alcoholic fatty liver is similar to what can be seen in liver disease caused by excessive alcohol consumption. Is NAFLD associated with a condition called insulin resistance, which in turn is associated with metabolic syndrome and type 2 diabetes mellitus. Obesity is a major cause of insulin resistance, metabolic syndrome, type 2 diabetes. NAFLD is the most common liver disease in the United States and is responsible for 24% of all liver diseases. In fact, the number of livers that are transplanted from non-alcoholic fatty liver, cirrhosis is related to the increase. The public health administrators that the current epidemic of obesity dramatically increases the development of nonalcoholic fatty liver and cirrhosis in the population.

• Cryptogenic cirrhosis (cirrhosis due to unidentified causes)

Cirrhosis due to unidentified causes, better known as Cryptogenic-Cirrhosis is a common reason for liver transplantation. It’s called cryptogenic cirrhosis because for years doctors have been unable to explain why a proportion of patients with cirrhosis developed. Doctors now believe that cryptogenic cirrhosis due to NASH (nonalcoholic steatohepatitis) caused by long-standing obesity, type 2 diabetes and insulin resistance. The fat in the liver of patients with NASH is estimated to disappear with the onset of cirrhosis, and this makes it difficult for physicians to establish the link between NASH and cryptogenic cirrhosis long. An important clue leading to NASH cryptogenic cirrhosis is the discovery of a large number of Nash in the new liver of patients undergoing liver transplantation in cryptogenic cirrhosis. Finally, a French study suggests that patients with NASH have a similar risk of developing cirrhosis patients with long-term infection with hepatitis C. (See below). However, it is expected that progression to cirrhosis from NASH to be slow and the diagnosis of cirrhosis is usually performed in patients in the sixties.

• Chronic Viral Hepatitis

Viral hepatitis chronic is a condition where chronic hepatitis B or chronic hepatitis C affects the liver for years. Most patients with viral hepatitis develop chronic hepatitis and cirrhosis. For example, most patients infected with hepatitis A recover completely within a few weeks without developing chronic infection. However, some patients infected with hepatitis B and most patients infected with hepatitis C develop chronic hepatitis, which in turn leads to progressive liver disease leading to cirrhosis and sometimes liver cancer.

• Inherited (genetic) disorders

Inherited genetic disorders that cause the accumulation of toxic substances in the liver, leading to tissue damage and cirrhosis. Examples include the abnormal accumulation of iron (hemochromatosis) or copper (Wilson’s disease). In hemochromatosis, patients inherit a tendency to absorb too much iron from food. Over time, iron accumulation in various organs in the body causes cirrhosis, arthritis, heart muscle damage leading to heart failure, and testicular dysfunction causing loss of sexual appetite. Treatment aims to prevent organ damage from the removal of iron in the body by bleeding (blood removal). In Wilson’s disease, is an inherited abnormality in one of the proteins that control copper in the body. Over time, copper accumulates in the liver, eyes and brain. Cirrhosis, tremor, psychiatric disorders and other neurological disorders occur if the condition is not treated quickly. Treatment with oral medication that increases the amount of copper from the body in urine.

• Primary biliary cirrhosis (PBC)

PBC, better known as Primary Biliary Cirrhosis is a liver disease caused by abnormal immune system that is predominantly female. Abnormal immunity in PBC causes chronic inflammation and destruction of small bile ducts in the liver. The bile ducts are the passages in the liver, bile travels to the intestine. Bile is a liquid produced by the liver that contains substances necessary for digestion and absorption of fat in the intestine, and other compounds that are waste products such as bilirubin, a pigment. (Bilirubin is produced by the breakdown of hemoglobin in red blood cells.). Along with the gallbladder, bile ducts form the biliary tract. In the PBC, the destruction of small bile duct blocks the normal flow of bile into the intestine. As the inflammation continues to destroy more of the bile ducts, also extends to destroy liver cells nearby. That the destruction of hepatocytes of products, the scar tissue (fibrosis) forms and propagates in the areas of destruction. The combined effects of ongoing inflammation, scarring, and the toxic effects of waste accumulation leads to cirrhosis.

• Primary sclerosing cholangitis (PSC)

PSC, better known as Primary Sclerosing Cholangitis is a rare disease that occurs frequently in patients with ulcerative colitis. In the PSC, the large bile ducts outside the liver become inflamed, narrowed and blocked. Outflow obstruction of the bile duct in biliary tract infections and jaundice, and eventually causes cirrhosis. In some patients, bile duct injury (usually after surgery) can also cause obstruction and cirrhosis of the liver.

• Autoimmune hepatitis

Autoimmune hepatitis is a liver disease caused by abnormal immune system that occurs most often in women. The abnormal immune activity in autoimmune hepatitis resulting in inflammation and progressive destruction of liver cells (hepatocytes), which eventually leads to cirrhosis.

• Babies can be born without bile ducts (biliary atresia)

Biliary atresia, also known as infant can be born without bile ducts and eventually develop cirrhosis. Other babies are born without enzyme vital for control of sugar that leads to the accumulation of sugars and cirrhosis. On rare occasions, the absence of a specific enzyme can cause cirrhosis and scarring of the lungs (alpha-1 antitrypsin deficiency).

• Other less common causes of cirrhosis include unusual reactions to certain drugs and exposure to toxins, and chronic heart failure (cardiac cirrhosis)

In some parts of the world (especially North Africa), infection of the liver parasites (schistosomiasis) is the most common cause of liver disease and cirrhosis.

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